Dr. Temperence Brennan is a brilliant, but lonely, forensic anthropologist who works at the Jeffersonian Institute in Washington D.C. After consulting on a case for the FBI, she is approached by Special Agent Seeley Booth. He wants Dr. Brennan to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booth, creating a volatile relationship for the two. However as their case load increases the symbiotic partnership produces results. With the support of Brennan's Squint Squad, murderers, past and present should be on the look out.